GENETIC TESTING

Prevention is key at Randox Health, where our aim is to identify risk factors for disease and motivate our clients to be proactive about their health. With advances in genomics and the study of the human genome (the entire human DNA sequence), it is now possible to screen for large numbers of inherited conditions in one test.

Randox Genomics Services, now available at Randox Health, provides genetic testing for genes associated with a range of cancers and cardiac conditions. Our testing can help you discover if you are at risk of developing cancer or an inherited cardiac condition.

Genetic Cancer Testing

Full Cancer Gene Panel £999


The Full Cancer Gene Panel is an extensive cancer genetics test covering 94 different genes suspected to play a role in predisposing to cancer. The panel includes tests for genes associated with both common (e.g., breast, ovarian, prostate, bowel) and rare cancers (e.g., thyroid cancer).

Cancer genes tested:

AIP DDB2 FANCL PALB2 SLX4
ALK DICER1 FANCM PHOX2B SMAD4
APC DIS3L2 FH PMS1 SMARCB1
ATM EGFR FLCN PMS2 STK11
BAP1 EPCAM GATA2 PRF1 SUFU
BLM ERCC2 GPC3 PRKAR1A TMEM127
BMPR1A ERCC3 HNF1A PTCH1 TP53
BRCA1 ERCC4 HRAS PTEN TSC1
BRCA2 ERCC5 KIT RAD51C TSC2
BRIP1 EXT1 MAX RAD51D VHL
BUB1B EXT2 MEN1 RB1 WRN
CDC73 EZH2 MET RECQL4 WT1
CDH1 FANCA MLH1 RET XPA
CDK4 FANCB MLH2 RHBDF2 XPC
CDKN1C FANCC MSH6 RUNX1
CDKN2A FANCD2 MUTYH SBDS
CEBPA FANCE NBN SDHAF2
CEP57 FANCF NF1 SDHB
CHEK2 FANCG NF2 SDHC
CYLD FANCI NSD1 SDHD

Core Cancer Gene Panel £850


The Core Cancer Gene Panel targets 29 key genes associated with many common cancers, including bowel, breast, ovarian, pancreatic, prostate and skin cancer.

Cancer genes tested:

APC CHEK2 MSH6 PTEN STK11
ATM FLCN MUTYH RAD51C TP53
BMPR1A MEN1 NBN RAD51D TSC1
BRCA1 MET PALB2 RB1 TSC2
BRCA2 MLH1 PMS1 RET VHL
CDKN2A MSH2 PMS2 SMAD4  

Breast & Ovarian Cancer Gene Panel £600


The Breast & Ovarian Cancer Gene Panel targets 8 key genes associated with hereditary breast and ovarian cancer.

Cancer genes tested:

ATM BRCA1 BRCA2 CDH1
CHEK2 PALB2 PTEN TP53

Genetic Cardiac Testing

Full Cardiac Gene Panel £999


The Full Cardiac Gene Panel is an extensive cardiac genetics test covering 174 different genes. The panel includes tests for genes associated with 17 different inherited cardiac conditions, including cardiomyopathies (diseases that affect the heart muscle and can lead to heart failure), arrhythmias (conditions that cause abnormal heart rhythms) and familial hypercholesterolaemia (a genetic predisposition to high cholesterol and premature heart disease).

Cardiac genes tested:

ABCC9 DOLK KCNJ5 PRDM16 TNNC1
ABCG5 DPP6 KCNJ8 PRKAG2 TNNI3
ABCG8 DSC2 KCNQ1 PRKAR1A TNNT2
ACTA1 DSG2 KLF10 PTPN11 TPM1
ACTA2 DSP KRAS RAF1 TRDN
ACTC1 DTNA LAMA2 RANGRF TRIM63
ACTN2 EFEMP2 LAMA4 RBM20 TRPM4
AKAP9 ELN LAMP2 RYR1 TTN
ALMS1 EMD LDB3 RYR2 TTR
ANK2 EYA4 LDLR SALL4 TXNRD2
ANKRD1 FBN1 LDLRAP1 SCN1B VCL
APOA4 FBN2 LMF1 SCN2B ZBTB17
APOA5 FHL1 LMNA SCN3B ZHX3
APOB FHL2 LPL SCN4B ZIC3
APOC2 FKRP LTBP2 SCN5A
APOE FKTN MAP2K1 SCO2
BAG3 FXN MAP2K2 SDHA
BRAF GAA MIB1 SEPN1
CACNA1C GATAD1 MURC SGCB
CACNA2D1 GCK2 MYBPC3 SGCD
CACNB2 GJA5 MYH11 SGCG
CALM1 GLA MYH6 SHOC2
CALR3 GPD1L MYH7 SLC25A4
CASQ2 GPIHBP1 MYL2 SLC2A10
CAV3 HADHA MYL3 SMAD3
CBL HCN4 MYLK SMAD4
CBS HFE MYLK2 SNTA1
CETP HRAS MYO6 SOS1
COL3A1 HSPB8 MYOZ2 SREBF2
COL5A1 ILK MYPN TAZ
COL5A2 JAG1 NEXN TBX20
COX15 JPH2 NKX2-5 TBX3
CREB3L3 JUP NODAL TBX5
CRELD1 KCNA5 NOTCH1 TCAP
CRYAB KCND3 NPPA TGFB2
CSRP3 KCNE1 NRAS TGFB3
CTF1 KCNE2 PCSK9 TGFBR1
DES KCNE3 PDLIM3 TGFBR2
DMD KCNH2 PKP2 TMEM43
DNAJC19 KCNJ2 PLN TMPO

Core Cardiac Gene Panel £850


The Core Cardiac Gene Panel targets 29 key genes associated with inherited cardiac conditions, including cardiomyopathies (diseases that affect the heart muscle and can lead to heart failure), arrhythmias (conditions that cause abnormal heart rhythms) and familial hypercholesterolaemia (a genetic predisposition to high cholesterol and premature heart disease).

Cardiac genes tested:

ACTA2 FBN1 KCNQ1 MYL2 TGFBR1
APOB HFE LDLR NOTCH1 TGFBR2
DSC2 KCNE1 LDLRAP1 PCSK9 TNNI3
DSG2 KCNE2 LMNA PKP2 TNNT2
DSP KCNH2 MYBPC3 RYR2 TTN
ELN KCNJ2 MYH7 SCN5A

Familial Hypercholesterolaemia Gene Panel £500


The Familial Hypercholesterolaemia Gene Panel includes 5 key genes known to cause familial hypercholesterolaemia, a condition characterised by very high cholesterol levels and premature heart disease.

Cardiac genes tested:

APOB APOE LDLR LDLRAP1 PCSK9

What does a genetic test involve?

Initial consultation
A Randox Health scientist will talk you through the test process and discuss the details of the genetic tests being undertaken. The scientist may ask questions about your family history to build a more detailed picture of your genetic risk and discuss with you the potential impact of genetic results for both you and your family.

Sample collection
Genetic testing requires a simple blood sample; no specific preparations are necessary.

Analysis
DNA analysis is performed within our own laboratory in Northern Ireland, with results available within 6 weeks.

Results
You will receive a written report describing your results. Your report will highlight key variants identified with significance for risk of disease, including clinical interpretation and advice regarding next steps, where applicable*

*Please note that Randox Health does not provide Genetic Counselling services. For detailed advice on the interpretation, inheritance patterns and clinical impact of your genetic results, we recommend that you see a genetic counsellor or another appropriate specialist.

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